Zepbound® Injection
The most effective FDA‑approved weight loss injection available — a once‑weekly dual GIP/GLP‑1 therapy with up to 22.5% weight loss in clinical trials.
Tirzepatide Injection — Once‑Weekly Dual GIP/GLP‑1 Therapy
Pre‑Filled Pen
Single‑Dose VialTwo Convenient Options
Zepbound® is available as a pre‑filled auto‑injector pen or a single‑dose vial, both administered once weekly. Our physicians will help you choose the option that fits your lifestyle and preferences.
- Dual GIP/GLP‑1 receptor agonist
- Up to 22.5% body weight loss in clinical trials
- Once‑weekly subcutaneous injection
- Available in pen or vial format
- Gradual dose escalation (2.5 mg – 15 mg)
- Manufactured by Eli Lilly
Why Choose Zepbound®?
Zepbound® (tirzepatide) is the only weight loss medication that targets two key metabolic hormones for superior results.
Dual GIP/GLP‑1 Action
Unlike single‑target GLP‑1 medications, Zepbound® activates both GIP and GLP‑1 receptors, addressing two hormones involved in appetite regulation, insulin sensitivity, and metabolism.
Up to 22.5% Weight Loss
In the SURMOUNT clinical trial program, patients on the highest dose of Zepbound® lost up to 22.5% of their body weight over 72 weeks — the highest weight loss seen in any FDA‑approved medication trial.
Simple Once‑Weekly Injection
Zepbound® is administered using a pre‑filled, single‑dose pen or vial. One quick subcutaneous injection per week — in the abdomen, thigh, or upper arm.
How Zepbound® Works
A next‑generation approach to weight loss that works with your body's natural systems.
Appetite Control
Zepbound® signals the brain's appetite centers to reduce hunger and increase satiety, helping you feel satisfied with less food and reducing the urge to snack or overeat.
Metabolic Support
By activating both GIP and GLP‑1 pathways, Zepbound® supports healthy insulin function and may improve how your body processes and stores energy from food.
Slower Gastric Emptying
Zepbound® slows the rate at which food leaves your stomach, promoting longer‑lasting fullness after meals and naturally reducing calorie intake.
Cardiometabolic Benefits
Beyond weight loss, Zepbound® has shown improvements in blood sugar control, blood pressure, and cholesterol levels in clinical studies.
Dosing & Administration
Two convenient options — pre‑filled pen or single‑dose vial — both once weekly.
Pre‑Filled Pen
The Zepbound® pen is a disposable, pre‑filled auto‑injector. Simply select your injection site, press the pen to your skin, and the medication is delivered automatically. No mixing or preparation required.
Single‑Dose Vial
Zepbound® is also available in single‑dose vials for use with a syringe. Your physician or care team will demonstrate the proper technique and help you choose the format that's most comfortable for you.
Gradual Dose Escalation
Treatment starts at 2.5 mg weekly and is gradually increased over several months. Available doses include 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg. Your physician adjusts the dose based on your response and tolerability.
Flexible Scheduling
Inject on the same day each week, at any time of day, with or without meals. If you miss a dose, take it within 4 days — then resume your regular schedule.
Safety & Side Effects
Our physicians carefully manage your treatment to maximize results and minimize side effects.
Common Side Effects
The most common side effects are gastrointestinal: nausea, diarrhea, decreased appetite, vomiting, and constipation. These are typically mild to moderate and tend to improve as the dose is gradually escalated.
Important Safety Information
Zepbound® is not recommended for patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. Our pre‑treatment evaluation screens for all contraindications.
Zepbound® Injection FAQs
Common questions about Zepbound® (tirzepatide) injections.
Zepbound® is the only FDA‑approved weight loss medication that targets both GIP and GLP‑1 receptors. This dual‑action mechanism has demonstrated greater average weight loss in clinical trials compared to single‑target GLP‑1 medications like Wegovy®.
Most patients report minimal discomfort. The pre‑filled pen uses a small, fine needle, and the injection takes just a few seconds. The vial option also uses a thin needle. Our team will teach you the proper technique to ensure comfort.
Both deliver the same medication at the same doses. The pen is more convenient and doesn't require preparation, while the vial may offer cost advantages. Our physicians will help you decide based on your preferences and coverage.
Most patients notice reduced appetite within the first 2‑4 weeks. Visible weight loss typically begins within the first month, with results accelerating as the dose is increased. Patients in clinical trials saw an average of 22.5% body weight loss over 72 weeks.
Treatment duration is individualized. Many patients benefit from 12 months or longer of treatment. Our physicians will develop a long‑term plan tailored to your goals, including nutrition and lifestyle support for sustained results.
Coverage varies by plan. Many insurance plans are now covering Zepbound® for weight loss. Our team can help you with prior authorization, manufacturer savings programs, and self‑pay pricing options.
Ready to Start Zepbound®?
Schedule a free consultation to find out if Zepbound® is the right medication for your weight loss goals.